The Anti-SBNO1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-SBNO1 Antibody, Rabbit Polyclonal has been validated for the following applications: Immunocytochemistry, and Immunofluorescence.
Description
Strawberry Notch1 (Sbno1) is a novel chromatin factor of the helicase superfamily 2. Sbno1 knockout embryos die at the preimplantation stage without forming a blastocoel, and Cdx2 is not turned on even though both Yap and Tead4 reside normally in nuclei. Accordingly, Sbno1 acts on the trophectoderm-enhancer (TEE) of Cdx2, ensuring its robust and synergistic activation by the Yap/Tead4 and NICD/Rbpj complexes. Interestingly, this synergism is enhanced when cells are mechanically stretched, which might reflect that TE cells are continuously stretched by the expanding ICM and blastocoel cavity. In addition, the histone chaperone, FACT (FAcilitates Chromatin Transcription) physically interacts with Sbno1. SBNO1 is associated with neonatal testicular development. SBNO1 maintains spermatogonial stem cells (SSCs) by promoting the noncanonical Wnt pathway